The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Automatic public malware analysis services provide controlled, isolated and virtual environments to analyse malicious software samples. Unfortunately, malware is currently incorporating techniques to recognize execution onto a virtual or sandbox environment; when an analysis environment is detected, malware behaves as a benign application or even shows no activity. In this work, we present an empirical study and characterization of automatic PMAS, considering 26 different services. We also show a set of features that allow to easily fingerprint these services as analysis (...) environments; the lower the unlikeability of these features, the easier for us to fingerprint the analysis service they belong to. Finally, we propose a method for these analysis services to counter or at least mitigate our proposal. (shrink)

Primary progressive aphasia is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic, associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic, associated with semantic deficits and anterior temporal lobe atrophy; non-fluent associated with grammar and/or speech-motor deficits and inferior frontal gyrus atrophy. Here, we set out to investigate whether the three variants of PPA can be dissociated based on error patterns in a single language task. We (...) recruited 21 lvPPA, 28 svPPA, and 24 nfvPPA patients, together with 31 healthy controls, and analyzed their performance on an auditory noun-to-verb generation task, which requires auditory analysis of the input, access to and selection of relevant lexical and semantic knowledge, as well as preparation and execution of speech. Task accuracy differed across the three variants and controls, with lvPPA and nfvPPA having the lowest and highest accuracy, respectively. Critically, machine learning analysis of the different error types yielded above-chance classification of patients into their corresponding group. An analysis of the error types revealed clear variant-specific effects: lvPPA patients produced the highest percentage of “not-a-verb” responses and the highest number of semantically related nouns ; in contrast, svPPA patients produced the highest percentage of “unrelated verb” responses and the highest number of light verbs. Taken together, our findings indicate that error patterns in an auditory verb generation task are associated with the breakdown of different neurocognitive mechanisms across PPA variants. Specifically, they corroborate the link between temporo-parietal regions with lexical processing, as well as ATL with semantic processes. These findings illustrate how the analysis of pattern of responses can help PPA phenotyping and heighten diagnostic sensitivity, while providing insights on the neural correlates of different components of language. (shrink)

A new approach to landscape ecology involves the application of the eco-field hypothesis and the General Theory of Resources. In this study, we describe the putative eco-field of bark beetles as a spatial configuration with a specific meaning-carrier for every organism-resource interaction. Bark beetles are insects with key roles in matter and energy cycles in coniferous forests, which cause significant changes to forestry landscapes when outbreaks occur. Bark beetles are guided towards host trees by the recognition of semiotic signals using (...) a specific eco-field. These signals mainly comprise a group of scents, which are called the odourtope. Their interactions with other organisms occur by sharing relevant information from the eco-field networks in the forest ecosystem. The eco-field networks modulate the expansion of the realized semiotic niche of the bark beetle towards the potential semiotic niche. Moreover, the niche construction process can be initiated by interchanging signals among species living in the same place, where these signals allow the exploitation of the required resources. If different organisms are interdependent on signals in eco-field networks, then this process may result in the establishment of mutualistic relationships. This is an example of how evolutionary processes are initiated by the recognition of signals in a network of eco-fields. (shrink)

With the publication of these two volumes the ground has now been prepared for a long awaited event, the critical edition of the works of Henry of Ghent. Henry was one of the outstanding philosophizing-theologians at the University of Paris in the second half of the thirteenth century and, during the period between the death of Thomas Aquinas in 1274 and the ascendancy of John Duns Scotus near the beginning of the fourteenth century, no other Master surpassed him in terms (...) of influence or importance. During his tenure there as Master in the theology faculty, Henry conducted fifteen Quodlibetal disputes. His written versions of these, along with his Summa of ordinary Disputed Questions, constitute his most important surviving works. And of these, his Quodlibets rank first. Henry's philosophical and theological views were highly original and drew considerable reaction from other leading Masters of the time, especially from Giles of Rome, Godfrey of Fontaines, and somewhat later, from Duns Scotus. While his personal thought cannot be reduced to that of any earlier thinker or tradition, his views were heavily influenced by Augustine, by Avicenna, and by various other Neoplatonic currents. At the same time, while he was quite familiar with the texts and thought of Aristotle, he reacted strongly against the more radical form of Aristotelianism developed by Siger of Brabant, Boethius of Dacia, and other Masters in the Arts Faculty at Paris in the 1260s and 1270s. Aquinas's incorporation of many Aristotelian positions into his own thought was also suspect in Henry's eyes. Given this background, Henry himself may be regarded as an outstanding representative of the Neo-Augustinian philosophical current which surfaced at Paris around 1270, which triumphed with the condemnation of 219 propositions by Stephen Tempier, Bishop of Paris, in 1277, and which would continue to be a dominant philosophical force until the end of the century. The need for a critical edition of his Quodlibets and his Summa has long been recognized, since the only printed versions date from the sixteenth and seventeenth centuries. In these first two volumes of Henry's Opera omnia Macken has prepared the way for the critical edition of Henry's works and especially of his Quodlibets. Here one finds a valuable catalog, based on first-hand inspection, of the widely scattered manuscripts of Henry's works. The catalog also contains expert codicological descriptions of the contents of these manuscripts, including works whose authenticity remains doubtful. Manuscripts are also considered which contain works that treat ex professo of Henry's doctrine. This is followed by an appendix which surveys ancient references to other manuscripts allegedly containing Henry's works, which manuscripts have not yet been found. Then there is a Répertoire, not of manuscripts but of Henry's works themselves, including certainly authentic works, works of doubtful authenticity, and finally, in another short appendix, works which have been falsely ascribed to him. A third part of this survey of Henry's works is devoted to manuscripts of other writers who discuss Henry's doctrine ex professo. The two volumes conclude with all the necessary indices. One must congratulate Macken for the care, the industry, and the meticulous scholarship with which he has prepared these two volumes. Not only are they of great value to anyone interested in the manuscript tradition of Henry's works and doctrine; they also include helpful descriptions of the writings of many other medieval authors which are contained in many of these same manuscripts. They will undoubtedly be carefully combed for decades to come by other scholars interested in these same authors and manuscripts. These volumes will be indispensable for libraries of institutions making any serious claim to expertise in the history of medieval philosophical and theological thought. One can only wish Macken and his international team of collaborators every success in their next immediate task, the actual edition of Henry's most important works, his fifteen Quodlibetal Questions.--J.F.W. (shrink)

„Fenomenologia: natura, znaczenie, ograniczenia” to przekład publikacji Bernarda J. F. Lonergana pt. „Phenomenology” nature, significance, limitations”. Tenże dwunasty wykład kanadyjskiego filozofia o fenomenologii traktuje o jej definicji, przedmiocie, naturze, znaczeniu i zasługach oraz związkach z innymi naukami. Wprowadza czytelnika w główne koncepcje tej szkoły filozoficznej i zapoznaje z autorami, dla których ten sposób myślenia jest charakterystyczny. Filozof w szczególności zwraca uwagę na to, iż jest to metoda badań, w której istotną rolę odgrywa wgląd. Warto zauważyć, że kategoria wglądu w epistemologii (...) Bernarda J. F. Lonergana — XX-wiecznego myśliciela i księdza filozofującego na pograniczu fenomenologii, tomizmu i hermeneutyki — jest kluczowa. Przekładu dokonała Dominika Dziurosz-Serafinowicz. (shrink)

Background: Expanded newborn screening generates incidental results, notably carrier results. Yet newborn screening programmes typically restrict parental choice regarding receipt of this non-health serving genetic information. Healthcare providers play a key role in educating families or caring for screened infants and have strong beliefs about the management of incidental results. Methods: To inform policy on disclosure of infant sickle cell disorder (SCD) carrier results, a mixed-methods study of healthcare providers was conducted in Ontario, Canada, to understand attitudes regarding result management (...) using a cross-sectional survey (N = 1615) and semistructured interviews (N = 42). Results: Agreement to reasons favouring disclosure of SCD carrier results was high (65.1%–92.7%) and to reasons opposing disclosure was low (4.1%–18.1%). Genetics professionals expressed less support for arguments favouring disclosure (35.3%–78.8%), and more agreement with arguments opposing disclosure (15.7%–51.9%). A slim majority of genetics professionals (51.9%) agreed that a reason to avoid disclosure was the importance of allowing the child to decide to receive results. Qualitatively, there was a perceived “duty” to disclose, that if the clinician possessed the information, the clinician could not withhold it. Discussion: While a majority of respondents perceived a duty to disclose the incidental results of newborn screening, the policy implications of these attitudes are not obvious. In particular, policy must balance descriptive ethics (ie, what providers believe) and normative ethics (ie, what duty-based principles oblige), address dissenting opinion and consider the relevance of moral principles grounded in clinical obligations for public health initiatives. (shrink)

Objective To evaluate the modes of death and treatment offered in the last 24 h of life to patients dying in 10 Brazilian intensive care units (ICUs) over a period of 2 years. Design and setting Cross-sectional, multicentre, retrospective study based on medical chart review. The medical records of all patients that died in seven paediatric and three adult ICUs belonging to university and tertiary hospitals over a period of 2 years were included. Deaths in the first 24 h of (...) admission to the ICU and brain death were excluded. Intervention Two intensive care fellows of each ICU were trained in fulfilling a standard protocol (κ=0.9) to record demographic data and all medical management provided in the last 48 h of life. The Student t test, Mann–Whitney U test, χ2 test and RR were used for data comparison. Measurements and main results 1053 medical charts were included (59.4% adult patients). Life support limitation was more frequent in the adult group (86% vs 43.5%; p<0.001). A ‘do not resuscitate’ order was the most common life support limitation in both groups (75% and 66%), whereas withholding/withdrawing were more frequent in the paediatric group (33.9% vs 24.9%; p=0.02). The life support limitation was rarely reported in the medical chart in both groups (52.6% and 33.7%) with scarce family involvement in the decision making process (23.0% vs 8.7%; p<0.001). Conclusion Life support limitation decision making in Brazilian ICUs is predominantly centred on the medical perspective with scarce participation of the family, and consequently several non-coherent medical interventions are observed in patients with life support limitation. (shrink)

Here we prove that if T and T′ are strongly minimal theories, where T′ satisfies a certain property related to triviality and T does not, and T′ is model complete, then there is no computable embedding of Mod(T) into Mod(T′). Using this, we answer a question from [4], showing that there is no computable embedding of VS into ZS, where VS is the class of infinite vector spaces over Q, and ZS is the class of models of Th(Z, S). Similarly, (...) we show that there is no computable embedding of ACF into ZS, where ACF is the class of algebraically closed fields of characteristic 0. (shrink)

The complexity of the human mind and its interaction with the environment is one of the main epistemological debates throughout history. Recent ideas, framed as the 4E perspective to cognition, highlight that human experience depends causally on both cerebral and extracranial processes, but also is embedded in a particular sociomaterial context and is a product of historical accumulation of trajectory changes throughout life. Accordingly, the human microbiome is one of the most intriguing actors modulating brain function and physiology. Here, we (...) present the 4E approach to the Human Microbiome for understanding mental processes from a broader perspective, encompassing one's body physiology and environment throughout their lifespan, interconnected by microbiome community structure and dynamics. We review evidence supporting the approach theoretically and motivates the study of the global set of microbial ecosystem networks encountered by a person across their lifetime (from skin to gut to natural and built environments). We furthermore trace future empirical implementation of the approach. We finally discuss novel research opportunities and clinical interventions aimed toward developing low‐cost/high‐benefit integrative and personalized bio‐psycho‐socio‐environmental treatments for mental health and including the brain‐gut‐microbiome axis. (shrink)

The DSM-IV, like its predecessors, will be a major influence on American psychiatry. As a consequence, continuing analysis of its assumptions is essential. Review of the manuals as well as conceptually-oriented literature on DSM-III, DSM-III-R, and DSM-IV reveals that the authors of these classifications have paid little attention to the explicit and implicit value commitments made by the classifications. The response to DSM criticisms and controversy has often been to incorporate more scientific diversity into the classification, instead of careful inquiry (...) and assessment of the principal values that drive the nosologic process. Implications for psychiatric science and future DSM classifications are discussed. (shrink)

Background It has been suggested that researchers are obliged to offer summary findings to research participants to demonstrate respect for persons, and that this may increase public trust in, and awareness of, the research enterprise. Yet little research explores researchers' attitudes and practices regarding the range of initiatives that might serve these ends. Methods Results of an international survey of 785 eligible authors of genetics research studies in autism or cystic fibrosis are reported. Results Of 343 researchers who completed the (...) survey (44% response rate), the majority agreed that their team should (i) inform participants of summary findings (90.7%) and (ii) ensure they gain an awareness of developments in the field (86.9%). Additionally, the majority reported that in practice, their team (i) informs participants of summary findings (69.4%) and (ii) provides other types of relevant non-results information (eg, state of science in the field, opportunities for research participation) (67.9%). Conclusion Researchers endorsed the obligation of communicating with research participants by providing summary findings and other research-related information in equal measure. In light of these findings, it is suggested that while the provision of summary results may contribute to efforts to discharge the obligation of respect for persons, it may be neither a necessary nor a sufficient means to this end. (shrink)

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) -/- Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems.

El sacrificio humano es una imagen frecuente en las religiones antiguas, concretamente en la griega, y su estudio ha levantado numerosos enfrentamientos entre corrientes historiográficas distintas. Uno de los casos más sobresalientes es del culto a Zeus en el Monte Liceo, que aquí analizamos. Las fuentes literarias reflejan la creencia de los griegos en estos sacrificios humanos, así que podemos decir que los sacrificios fueron reales porque fueron usados para construir paisaje y, por lo tanto, realidad.